Period after conception
|
Major milestones
|
3
weeks
|
Optic groove appears
|
4th weeks
|
Optic pit develops into optic vesicle
Lens plate forms
Embryonic fissure develops
|
1
month
|
Lens pit and lens
vesicle form
Hyaloid vessels develop
|
11 months
|
Closure
of embryonic fissure
Differentiation
of retinal pigment epithelium
Proliferation
of neural retinal cells
Appearance
of eyelid folds and nasolacrimal duct.
|
7th
week
|
Formation
of embryonic nucleus of the lens
Sclera begins to form
Migration
of waves of neural crest
First
wave: Formation of corneal
and trabecular endothelium
Second
wave: Formation of corneal stroma
Third
wave: Formation of iris stroma.
|
3rd
month
|
Differentiation
of precursors
rods and cones
Anterior chamber appears
Fetal nucleus starts to develop
Sclera
condenses
Eyelid
folds lengthen and fuses
|
4th
month
|
Formation
of retinal vasculature begins
Hyaloid
vessels begins to regress
Formation
of physiological optic disc cup and lamina
cribrosa
Canal of Schlemm appears
Bowman's
membrane develops
Formation
of major arterial circle and sphincter muscles of iris.
|
5th
month
|
Photoreceptors
differentiation
Eyelid
separation begins
|
6th
month
|
Differentiation
of the dilator papillae muscle
Nasolacrimal
system becomes patent
Cones differentiate
|
7th
month
|
Rods differentiate
Myelination
of optic nerve begins
Posterior
movement of anterior chamber angle
Retinal
vessels starts reaching the nasal periphery
|
8th
month
|
Completion
of anterior chamber formation
Hyaloid
vessels disappears
|
9th
month
|
Retinal
vessels reach the temporal periphery
Pupillary
membrane disappears
|
After
birth
|
Macular region of the retina develops further
|
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